Source: http://social.technet.microsoft.com/Forums/exchange/en-US/5cb79acf-6fed-4e99-b092-6e3f923e325b/error-4001-source-msexchange-system-attendant-mailbox?forum=exchangesvrdeploylegacy
Answers
I have solved the issue but I am going to put the answer to your questions here in case anyone else has similiar symptoms.
I had run all these before and they all passed except when I ran the DCDiag /S:apr-tst-dc1 /Test
NS
/DNSRecordRegistration. If I ran that test on the domain controller,
it would pass. If I ran it on the Exchange server, it would fail. Even
after I fixed the 4001 Error, that behaviour still continues.

Anyway the solution was to update the drivers to the
most current version and then turn off "Offload Checksum" option on the
NIC. Once I did this, all my AD Replication errors and Exchange Errors
went away.
Tuesday, May 06, 2008 11:49 AM
American Profit Recovery
Source: http://social.technet.microsoft.com/Forums/exchange/en-US/5cb79acf-6fed-4e99-b092-6e3f923e325b/error-4001-source-msexchange-system-attendant-mailbox?forum=exchangesvrdeploylegacy
Also see the link or read below it here:source: http://social.technet.microsoft.com/Forums/exchange/en-US/2a9e0fde-ea91-46f9-a113-82c870aee609/information-store-is-stopped-4001-logged-in-eventviewer?forum=exchangesvradminlegacy
Answers
HI,
below article nicely describe about offload Checksumming,I have quote below statements from there.
below article nicely describe about offload Checksumming,I have quote below statements from there.
Quote When
data comes in through a network, it's "checksummed," meaning the data
is checked against a checksum (or validation code) in the headers in the
packets it was delivered in. If the data and checksum don't match, the
packet is determined to be bad and has to be retransmitted.
To speed things up, some network cards can "offload" the checksumming, i.e., perform the checksumming on the network card itself, rather than leave the job to the CPU. This frees up the CPU to do that much more work on its own and on a server with extremely high network throughput, that much CPU savings can add up.
To speed things up, some network cards can "offload" the checksumming, i.e., perform the checksumming on the network card itself, rather than leave the job to the CPU. This frees up the CPU to do that much more work on its own and on a server with extremely high network throughput, that much CPU savings can add up.
To disable checksum offloading:
1. Open the Registry and navigate to HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Tcpip\Parameters.
2. Add a new DWORD value named DisableTaskOffload and set it to 1.
3. You may need to restart the system to make these changes take effect.
Note:-Please take the backup of registry before do changes.
Resource
Regards
Chinthaka Shameera | MCITP: EA | MCSE: M | http://howtoexchange.wordpress.com/
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